Is Isaac Guerendo playing on "Thursday Night Football" or is he out? Is Isaac Guerendo injured or healthy for Week 15 TNF?

Can a trip to the desert snap Kirk Cousins (four games without a TD pass) out of his scoring drought? I think so.

Mike Shanahan weighs in on Patrick Taylor Jr., and how he and his son, Kyle, have gotten running back production from anyone ...

According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday ...

Join Packers Head Coach Matt LaFleur and analyst Larry McCarren as they discuss the Packers' Week 14 loss to the Lions and preview the Week 15 showdown in Seattle. This week's guest is Tucker Kraft.

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

Jared Hochman's NFL best bets and player props for Week 15, featuring San Francisco 49ers wide receiver Jauan Jennings ...

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for ...

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.