eLife1d
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest
In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable ...
eLife1d
Single cell transcriptomics reveals early photoreceptor states, cell-specific transcript isoforms, and cancer-predisposing features
Here, we used deep full-length single-cell RNA-sequencing to distinguish post-mitotic cone and rod developmental states and cone-specific features that contribute to retinoblastomagenesis. The ...
eLife2d
Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength
Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...
eLife2d
Layer 6 corticocortical cells dominate the anatomical organization of intra and interhemispheric feedback
Sainsbury Wellcome Centre for Neuronal Circuits and Behavior, University College London, London, United Kingdom ...
eLife2d
Enhanced bacterial chemotaxis in confined microchannels: Optimal performance in lane widths matching circular swimming radius
This valuable study examines the effects of side-wall confinement on the chemotaxis of swimming bacteria in a shallow microfluidic channel. The authors present solid experimental evidence, combined ...
eLife2d
CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells
This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...
eLife3d
The eLife Model: An update on progress following changes in Web of Science indexing status
Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing ...
eLife3d
Microbiome: Balancing microbial composition through diet
The gut of animals is a complex ecosystem consisting of trillions of bacteria and other microorganisms that are unique to every individual. Infants can inherit their first gut bacteria through vaginal ...
eLife3d
Spatial and temporal distribution of ribosomes in single cells reveals aging differences between old and new daughters of Escherichia coli
Differences in the ribosomal densities of the two daughters produced by a mother Escherichia coli could explain the asymmetry of aging and growth rate in previously reported such daughter pairs.
eLife3d
Auditory Cortex Learns to Discriminate Audiovisual Cues through Selective Multisensory Enhancement
Multisensory object discrimination is essential in everyday life, yet the neural mechanisms underlying this process remain unclear. In this study, we trained rats to perform a two-alternative ...
eLife3d
NE contribution to rebooting unconsciousness caused by midazolam
The results of central nervous regulation in mice provide a new neural circuit and receptor regulatory mechanisms for the recovery of consciousness after midazolam administration.
eLife3d
Information, certainty, and learning
The learning rate (left axis; as reciprocal of the number of trials to acquisition, right axis) plotted against the mutual information (log2 of informativeness) for the 14 groups. Note. The criterion ...