Alexander Joseph "Lex" Luthor is the main antagonist of the 2006 film Superman Returns, which serves as an homage sequel to the 1978 film Superman and its 1980 sequel Superman II, …

In Sonic the Hedgehog 2006, Mephiles the Dark emerged as an unintended result of the Solaris Project, initiated by the King of Soleanna. He adopted the form of Shadow the Hedgehog, …

The Pale Man is the secondary antagonist of the 2006 Spanish dark fantasy drama film Pan's Labyrinth. He is a pale skinned humanoid monster with his eyeballs in the palms of his hands, …

Stanley "Stan" Beals is the main antagonist of the 2006 Warner Bros. computer-animated film The Ant Bully. He is a flagitious exterminator who takes great pleasure in wiping out insects.

Connor Shepard, also known as Concussion, is the main antagonist of the 2006 superhero film Zoom. He is the older brother of Jack Shepard/Captain Zoom who went insane after he was …

Nigel Colbie is the primary antagonist of the 2006 Australian thriller film Like Minds. (Note: Like Minds was renamed Murderous Intent for its 2007 DVD Release).

Villains from the 2006 action-adventure video game Bully (released in the PAL region as Canis Canem Edit), made by the video game developer and publisher Rockstar Games.

Constance Nebbercracker, also nicknamed the Monster House, is the titular main antagonist of the 2006 Columbia Pictures computer-animated horror film of the same name.

Gwoemul (in Korean: 괴물, lit: "Monster") is the titular main antagonist of the 2006 South Korean monster film of the same name (released internationally as The Host). It is a mutated fish-like …

Dalton Russell is the villainous deuteragonist of the 2006 heist thriller film Inside Man. He is a professional criminal who pulls of an ambitious bank heist which soon leads to a hostage …