BRCA Gene Changes: Cancer Risk and Genetic Testing
The prevalence of harmful BRCA gene changes in the general population is about 0.2%–0.3% (or about 1 in 400). However, in certain populations that are geographically or culturally distinct, the prevalence …
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Key points: BRCA1/2 -associated ovarian cancers are more likely to have high-grade serous adenocarcinoma histologies. Occult lesions found in the fallopian tubes of BRCA carriers suggest …
Hoja informativa sobre los cambios en el gen BRCA y las pruebas …
Los cambios dañinos en BRCA que se detectan en el tumor pueden ser hereditarios o haber surgido en otro momento de la vida de la persona. Por este motivo, si se identifica un cambio en el tumor, es …
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
Apr 15, 2024 · For women with inherited harmful changes in BRCA genes, MRI surveillance and salpingo-oophorectomy can modestly reduce their risk of dying from breast and ovarian cancer, …
Cancer Risk for Women Carrying BRCA Mutations - NCI
Jul 12, 2017 · An international team of researchers has published results from the first large prospective study of breast and ovarian cancer risk in women who carry inherited BRCA mutations. The BRCA1 …
Discovery – BRCA Connection to Breast and Ovarian Cancer
As a result of NCI's investment, people with a family history of breast and ovarian cancer can use their BRCA test results to help make informed decisions about screening and potential risk-reducing …
Researchers categorize thousands of BRCA2 mutations as cancerous or ...
Feb 14, 2025 · A team of researchers led by Shyam K. Sharan, Ph.D., Senior Investigator in the Mouse Cancer Genetics Program, has categorized over 6,500 possible single nucleotide variants (SNVs) in …
Genetic Testing Fact Sheet - NCI - National Cancer Institute
As of January 2024, the only FDA-approved DTC genetic test for inherited cancer risk tests for three different BRCA gene variants that are common in people of Ashkenazi Jewish descent.
Surgery to Reduce the Risk of Breast Cancer
Dec 2, 2025 · People with a harmful BRCA variant who have surgery to treat breast cancer may also consider having risk-reducing salpingo-oophorectomy to improve their long-term outcomes.
Genetic and Genomic Testing Recommendations
A known mutation in the breast cancer (BRCA) genes in someone in the family. Genetic testing is recommended for individuals who have had colorectal (colon) or uterine (endometrial) cancer and …