Interleukin 12 - Wikipedia
IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. [2] Despite sharing many structural features …
Immunology of IL-12: An update on functional activities and ...
As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by …
The Immunobiology of the Interleukin-12 Family: Room for Discovery
The IL-12 family of cytokines influences the outcome of cancer, infection, and inflammatory diseases. Stumhofer, Hunter, and Tait review the combinatorial biology inherent to this family and the recent …
IL-12 Cytokine: A Driver of Immunity and Disease
Jun 30, 2025 · IL-12 is a driver of the Type 1 immune response, which is specialized to combat intracellular pathogens such as viruses and certain bacteria. This response is characterized by cell …
IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop ... - Nature
Jun 11, 2024 · We identify IL-12 as a cytokine switch, acting directly on B cells to promote extrafollicular and suppress germinal center responses.
IL-12 family cytokines and autoimmune diseases: A potential …
Jun 1, 2025 · In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases.
Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis ...
Interleukin 12 (IL-12) family is comprised of 4 members, IL-12, IL-23, IL-27 and IL-35. IL-12, IL-23 and IL-27 are secreted by activated antigen presenting cells (APC) during antigen presentation to naïve T …
IL-12 Signaling: Key Insights into Immune Response
Discover the critical role of IL-12 signaling in immune responses. Explore its mechanisms, effects on immune cells, and implications for diseases like cancer and autoimmunity. 💉🧬
New nanoparticles stimulate the immune system to attack ovarian …
Oct 31, 2025 · MIT researchers designed nanoparticles that can deliver an immune-stimulating molecule called IL-12 directly to ovarian tumors. When given to mice along with checkpoint inhibitors, the …
Structure and assembly of the human IL-12 signaling complex
Aug 6, 2024 · Chen et al. determined the cryo-EM structure of the human IL-12/IL-12Rβ1/IL-12Rβ2 complex. The structure reveals two distinctive conformational states of IL-12 and structural plasticity …