After a decade as the anchor of "NBC Nightly News," Lester Holt is starting a new chapter in his journalism career. | USA TODAY Video

Lester Holt signs off at the end of his first broadcast as anchor of #NBCNightlyNews | NBC Nightly News with Tom Llamas

Gov. Cuomo responds to President Trump, who said he doesn't believe New York needs 30,000 ventilators. "I hope no one needs a ventilator," Cuomo told Lester Holt today. "But I don't operate on what I hope...I operate on the data..." Watch the interview tonight on Nightly News. | NBC Nightly News with Tom Llamas

"One pill could kill. One pill, one time, game over." Tonight on NBC Nightly News, Lester Holt talks to Cheri Oz, Special Agent in Charge of the DEA's Phoenix Field Division, about the fentanyl crisis. Watch the full report at 6:30 pm ET / 5:30 pm CT (check local listings). | NBC Nightly News with Tom Llamas

Ahead for us on NBC Nightly News with Lester Holt: > Lester Holt speaks with CDC Director Dr. Rochelle Walensky about the omicron variant. > Stephanie Ruhle follows the journey of a single sweater to explain the impact of supply chain slowdowns. And much more. Join us on your local NBC station. | NBC Nightly News with Tom Llamas